Parkinson Disease

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Also Known As:

Parkinson's Disease; Idiopathic Parkinson's Disease; Parkinsonism, Primary; Lewy Body Parkinson's Disease; Parkinson Disease, Idiopathic; Parkinson's Disease, Idiopathic; Parkinson's Disease, Lewy Body; Idiopathic Parkinson Disease; Lewy Body Parkinson Disease; Paralysis Agitans; Primary Parkinsonism

Nervous System Diseases: 14737
- Neurodegenerative Diseases: 44095
  - Synucleinopathies: 2238
    - Parkinson Disease: 61226
- Central Nervous System Diseases: 4371
  - Brain Diseases: 16141
    - Basal Ganglia Diseases: 350
      - Parkinsonian Disorders: 9322
        Parkinson Disease: 61226
  - Movement Disorders: 4780
    - Parkinsonian Disorders: 9322
      - Parkinson Disease: 61226

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Drug/Important Bio-Agent (IBA)